In New York City, a group of women led by a mysterious, charismatic figure known as The Madame band together to wage a violent war against their male oppressors. These righteous assassins abide by a strict ideological code that forbids them from killing women or being romantically involved with men. 

When a moral dilemma causes Scarlet Rose, one of the founding members of the group, to go into hiding, her young protege, Sadie Mars, an ardent believer in their violent feminist code, takes it upon herself to find Scarlet and uncover the truth behind her mentor’s betrayal.